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Melanotan II is a peptide hormone belonging to the alpha-melanocyte-stimulating hormone (alpha-MSH) class of mimetics. Melanotan II is a synthetic analog pituitary derived Melanocortin. The peptide is primarily known for its ability to help with tanning but is also used to aid in erectile function. Melanotan II, also referred to as MT-2, has no use of significance beyond tanning and erectile function.
Melanotan II (MT-2) functions by stimulating the alpha-MSH receptor. This is a receptor that produces melanin, which aids in the darkening of skin pigmentation. Because of this action, the individual will tan easier and darker than he would without the use of MT-2.
There are several alpha-MSH receptors in the body. Melanotan II functions by stimulating the MC1-5 receptor. Stimulation of this receptor promotes darkening of the skin. MT-2 also stimulates the MC4 receptor, which acts to increase penile erectile function.
Clinical trials have shown promising results for Melanotan II in regards to erectile dysfunction. However, despite clinical trials the peptide has never been approved by the U.S. government for human use:
2000 - UAZ College of Medicine (Urology) - Findings: Promoted erections in 17 of 20 subjects, tip rigidity increased by 80%. 68% experienced increase in libido.
1998 - UAZ College of Medicine (Pharmacology) - Findings: Promoted erections in 80% of men, tip rigidity increased by 80%.
Note - all erectile dysfunction studies are based on psychogenic erectile dysfunction, which refers to erectile dysfunction of a physiological nature not a physical one. However, many anecdotal reports state stronger erections and better performance when used as a sex aid despite no existing erectile dysfunction.
The effects of Melanotan two revolve around nothing more than tanning and possible erectile dysfunction relief. A darker and deeper tan may be noticed in a few days (assuming one is also tanning) and should produce notable results in a few weeks. The longer one uses MT-2 the darker he will get.
The effects of Melanotan II on erectile dysfunction take approximately 4-6 hours to take effect and should last 6-12 hours depending on individual response. Timing is important if used for this purpose. However, there are those that run small daily to every other day doses in order to provide a maintenance relief, but this can prove problematic to the skin if not careful.
The most common side effect of Melanotan II is appetite suppression, but it should not be as significant as one might associate with diet or fat loss medications. Nausea and fatigue or a lightheaded feeling can also be somewhat common in some individuals. Such effects may be strong but should clear quickly. Dosing may need to be reduced should such effects occur until a more comfortable level is reached.
The side effects of Melanotan II can also include the darkening of hair, although not significantly. It may also include the darkening of moles, and in some cases, may be cause to discontinue use. Darkening of moles is the one side effect of Melanotan II an individual would want to keep a close eye on.
Melanotan II is provided in freeze-dried (lyophilized) form and reconstituted with bacteriostatic water. MT-2 may be injected subcutaneously or intramuscularly with subcutaneous being the most common and convenient. Melanotan II should be kept refrigerated at all times, and should be discarded in 30 days after reconstitution.
Melanotan II is typically taken at a dose of 0.5-2mg per day with 0.5-1mg being enough for most individuals who use it for tanning purposes. The same 0.5-1mg dosing is sufficient for erectile dysfunction treatment.
